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Mechanism Responsible for Development of Idiopathic Pulmonary Fibrosis Identified

A group of scientists from Helmholtz Zentrum München, in collaboration with colleagues from the University of Denver, have uncovered a contributing mechanism responsible for the development of idiopathic pulmonary fibrosis (IPF).

In the study published in the American Journal of Respiratory and Critical Care Medicine, the teams found that increased extracellular vesicles (EVs) function as carriers for signaling mediators, such as WNT-5A, in IPF and contribute to disease pathogenesis as a result. The team also concluded that novel approaches to diagnose and develop treatments for IPF may be possible with this characterization of EV secretion and composition.

"Simply put, extracellular vesicles are tiny pouches released by cells that can contain a large number of messenger substances, such as proteins and nucleic acids," explained Dr. Mareike Lehmann, one of the authors of the study, in a recent statement. "They are an important means of communication between cells and organs and help to ensure that the substances reach completely new sites."

In order to characterize EVs and evaluate the function of EV-bound WNT signaling in IPF, the teams “isolated EVs from bronchoalveolar lavage fluid (BALF) from experimental lung fibrosis as well as samples from IPF, non IPF-ILD, non-ILD and healthy volunteers from 2 independent cohorts,” authors of the study write. Through the use of transmission electron microscopy, nanoparticle tracking analysis, and Western Blotting (WB) investigators were able to characterize the EVs. Metabolic activity assays, cell counting, quantitative PCR, and WB upon WNT gain- and loss-of-function studies were used to analyze primary human lung fibroblasts (phLFs), which were used for EV isolation, the authors write.

Full Article: https://www.raredr.com/news/mechanism-responsible-development-idiopathic-pulmonary-fibrosis-identified

Source: Rare DR - Rare Disease Report  - By: Krista Rossi

Blood Test May Predict Tumor Metastasis in Head and Neck Cancers

Researchers in Australia are developing a simple test using blood samples to determine if patients with rare head and neck cancers are at risk of having their cancer spread to other organs.

According to the National Institutes of Health’s (NIH) National Cancer Institute, head and neck cancers make up about 4% of all cancer cases in the United States. Individuals who have been diagnosed with head or neck cancer are at greater risk of developing secondary cancer, such as in the esophagus or lungs, and the chance is higher for those who consume tobacco or alcohol products.

Just who is at risk for developing secondary cancers, or distant metastasis, has been the focus of researchers from Australia’s Queensland University of Technology. In a recent study published in the journal Nature Scientific Reports, the researchers say they’ve found that a simple liquid biopsy using blood samples may help predict which head and neck cancer cases may spread. In a study of 60 patients with head and neck cancers, the research team examined blood samples containing clusters of circulating tumor cells (CTCs) – which are shed from primary or secondary tumors and then circulate in patients’ blood – using a device developed by the team to separate single CTCs and CTC clusters from the blood of cancer patients.

Full article: https://www.raredr.com/news/blood-test-may-predict-tumor-metastasis-in-head-and-neck-cancers

Source: Rare DR - Rare Disease Report

By Einav Keet 

Five Facts About: Amytrophic Lateral Sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS)- which is also commoly referred to as "Lou Gehrig's Disease" because of how little was known about it at the time of the baseball legend's diagnosis- is a classis motor neuron disease. Early symptoms include muscle weakness or stiffness, but as the disease evolves, the abilities to move, speak, swallow, and eventually breathe are rapidly lost. 

Full article: http://www.raredr.com/news/five-facts-about-als

Source: Rare DR - Rare Disease Report by Mathew Shanley 

 

Rare Disease Day 2018 on February 28th

Show Your Rare for

Rare Disease Day 2018!

Rare Disease Day has become iconic as the global campaign for raising awareness of the impact that rare diseases have on the lives of patients and those who care for them.

patient-led campaign, Rare Disease Day was launched by EURORDIS and its Council of National Alliances in 2008 and brings together millions of patients, families, carers, medical professionals, policy makers and members of the public in solidarity.

In 2018, organisations in over 90 countries and regions around the world are participating in Rare Disease Day by holding local eventsFor the first time ever, TogoGhana, and Trinidad and Tobago will participate in Rare Disease Day!

The theme for Rare Disease Day 2018 is research. Rare Disease Day 2018 offers participants the opportunity to be part of a global call on policy makers, researchers, companies and healthcare professionals to increasingly and more effectively involve patients in rare disease research.

Dia Mundial do doenca rara

Get involved in Rare Disease Day 2018!

Everyone can get involved in Rare Disease Day, those affected and unaffected by rare diseases alike:

>>Show Your Rare on social media

Take part in the interactive #ShowYourRare social media campaign during the month of February - paint your face and share your selfie on social media to show your support for the rare disease community! See the EURORDIS team getting involved.

Prefer not to paint your face? See alternative ways to get involved, including printing this social media boardand holding it up in your photos!

Sean Hepburn Ferrer, eldest son of the late Audrey Hepburn who passed away from rare cancer pseudomyxoma adenocarcinoma, is Rare Disease Day Ambassador for the fifth year. See him getting involvedin the #ShowYourRare campaign.

You can also add this Facebook filter or this Twitter filter to your profile picture.

And don’t forget to sign up to the Rare Disease Day Thunderclap campaign to automatically share a message of support on your Twitter or Facebook account on 28 February.

>>Rare Disease Day 2018 official video & poster

Watch and share the official video (available in over 30 languages!). This year’s video pays tribute to the role patients play in research. The video features patients and family members, researchers and doctors who show their rareRead their stories! Thank you to Publicis Health for their in-kind contribution to the campaign and Madame Peel for the production of the video. 

You can also download the official Rare Disease Day 2018 poster, logo and social media banner to use at your events and online.

>>Become a friend of Rare Disease Day

Everyone (organisations, companies, caregivers and researchers) can become a friend of Rare Disease Day to show support for the 2018 campaign!

>>Your Rare Disease Day events 

Since Rare Disease Day began, thousands of events have been held throughout the world, reaching hundreds of thousands of people.

Are you holding an event for Rare Disease Day 2018? Post your event on rarediseaseday.org so that people living in your country can find out about your Rare Disease Day activities.

>>Tell your story

You can also tell your rare disease story on rarediseaseday.org.

Twitter header

Source: https://www.eurordis.org/pt-pt/news/apoie-doencas-raras-mostre-o-no-dia-das-doencas-raras-de-2018

By: Eva Bearryman, Communications Manager, EURORDIS

Pictures: rarediseaseday.org

 

 

2017 Was the Year of Gene-Therapy Breakthroughs

Gene-fixing treatments have now cured a number of patients with cancer and rare diseases.

It was a notable year for gene therapy. The first such treatments in the U.S. came to market this year after winning approval from the Food and Drug Administration. Meanwhile, researchers announced more miraculous cures of patients with rare and life-threatening diseases who were treated with experimental therapies.

Decades in the making, gene therapy—the idea of modifying a person’s DNA to treat disease—represents a major shift in medicine. Instead of just treating symptoms like the vast majority of drugs on the market, gene therapy aims to correct the underlying genetic cause of a disease. Doctors and scientists hope these treatments will be a one-shot cure.

Last year, we wrote that 2016 was gene therapy’s most promising year. But 2017 proved to be even bigger.

Read the 2017 gene therapy breakthroughs full article: 

https://www.technologyreview.com/s/609643/2017-was-the-year-of-gene-therapy-breakthroughs/

Sources: MIT Technology Review 

By Emily Mullin

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